Sanguinarine is an alkaloid studied in the treatment of cancer cell proliferation. Found in several plants with Argemone mexicana Linn, the plant is used in traditional medicine from several countries with Mexico and India in the natural treatment of wounds, conjunctivitis and as hallucinogen. Due to these studies of this alkaloid, a study was made on a molecular structure of the sanguinarine, through quantum chemistry, via computational methods such as molecular mechanics, PM3, Hartree-Fock, density functional theory and Møller-Plesset. The main site of molecular interaction was determined to be the hydrogen atoms. This has a strong antioxidant potential in its structure. It probably interacts with free radicals reducing their carcinogenic effect on cells. A study of the infrared spectrum complemented the paper.
Comments: 23 Pages. Malaysian Journal of Chemistry, 2018, Vol. 20(1), 1 – 23. Key words: Density functional theory; Hartree-Fock, Møller-Plesset; molecular geometry; quantum chemistry, PM3; sanguinarine. Received: March 2018; Accepted: April 2018.
[v1] 2018-07-09 08:08:26
Unique-IP document downloads: 20 times
Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.