Quantitative Biology

2510 Submissions

[3] viXra:2510.0143 [pdf] submitted on 2025-10-28 20:40:15

An Accurate Bell Curve Discovered in Intraspecific Body Mass Distribution of 1k Beetles

Authors: Nagi Nangirky Ogata, Norichika Ogata
Comments: 4 Pages. 1 figure, 10 references

While the normal distribution is often termed "normal," it is uncommon to encounter precise bell curves in biological measurements. In this study, we discovered an accurate normal distribution in the intraspecific body mass distribution of the Scarab Beetle Anomala albopilosa. We captured over thousands of beetles and measured their weight, and we also conducted a Mark-Release-Recapture study.
Category: Quantitative Biology

[2] viXra:2510.0115 [pdf] submitted on 2025-10-24 21:28:23

Synergistic and Antagonistic Effects of Drug Combinations on Tumor Cell Migration in a Fibroblast Scratch Assay Model

Authors: Daniel Suh, Akhil Patel, Sriyan Daggubati
Comments: 5 Pages.

This study examined the effects of 12 biochemical agents, including chemotherapies, a dilution series of Etoposide, copper (II) ions, and other bioactive compounds, on tumor cell migration using a fibroblast scratch assay. Agents were applied to adult mouse fibroblasts, and migration was quantified via microscopy and cell counts. Chemotherapies such as 5-Fluorouracil, Cytarabine, Etoposide, and Cycloheximide showed varied effects based on mechanisms like DNA synthesis inhibition and apoptosis induction. Copper (II) ions and Vanadate promoted mitochondrial damage and tumor suppressor activation, while Retinoic Acid inhibited proliferation and metastasis-related signaling. Resveratrol demonstrated the strongest inhibition of cell migration, with logistic growth modeling suggesting lasting effects on tumor proliferation. These results highlight how Resveratrol can act as a dual-action therapeutic and support further investigation into its use in cancer treatment.
Category: Quantitative Biology

[1] viXra:2510.0081 [pdf] submitted on 2025-10-15 00:42:15

Gene Expression Analysis For Lychee Under The Influence Of Peronophythora Litchii

Authors: Eric Zhuang
Comments: 14 Pages.

Lychee (Litchi chinensis Sonn.) is a delicious and nutritious fruit that can be infected by a plant pathogen called Peronophythora litchii. In this study, our main hypothesis is that Lychee with or without the inoculation of P. Litchii should exhibit a set of differentially expressed genes that can be further analyzed.Although a whole genome sequence was recently completed, research on the functionality of individual genes under the stress of P. Litchii is scarce. In this work, we acquired a genome-wide transcriptomic data for two cultivars of Litchi with and without P. Litchii treatments from the NCBI Gene Expression Omnibus (GEO) database. We then used Deseq2 library to identify and analyze differentially expressed genes. In addition, we studied the top 18 differentially expressed genes by locating them on the chromosome, describing their gene structure and finding out a number of conserved motifs. Furthermore, we investigated the promoter area of those genes (2000 bp upstream) and identified 7 cis-regulatory elements such as ABRE, ARE, MeJA, TCA that are related to disease response and defense. This will aid in developing new lychee cultivars that can better resist the infection of P. Litchii.
Category: Quantitative Biology