Quantitative Biology

The H-Bond Breakdown Switch Allows DNA and Protein Transitions in the Brain to Control the Dynamics of Hormonal Communication and Learning Vocalization

Authors: Alfred Bennun
Comments: 37 Pages. 12 figures

The choroid plexus epithelium (CPE) generates cerebrospinal fluid (CSF) in a mutual exclusive vectorial kinetic according to a potential of hydrophilic-plasma 0mV -60mV to hydrophobic-CSF +4mV. Astrocytes are cells with actin filaments for pulsatile propulsion in the cell’s skeleton, bi-directional transport of ions gradient Na+, which impulses the CSF flux into the lumen along a glial network. Luminal K+ is required for sustained CSF secretion. At ventricular side, the Na+/K+-ATPase releases the Na+. Quantum mechanics microtubules nano scale (10-9m) flow a parallel transportation from the exterior to the nuclei of glucose, nascent Mg2+, O2, etc., and antiparallel of dimers. The microtubule diameter allows a very small number of molecules in a minimal volume to reach a saturation state for enzyme activity. An increasing in the number of random collisions allows to concatenate Na+/K+ translocation into nano space at minimal capacitance to operate at maximal voltage. Myelination discontinuity at the Ranvier nodes allows open systems exchanges with CSF to re-supply the optimal ion concentration to maintain rapid transmission of the propagation of the action potential. The Doppler shift could tune in with the spin-flip of electrons of a 21 cm line of hydrogen, operating as an antenna for the neuronal membrane action potential state of firing for vectorial networking. Thus, synchronizing the electric potential by a sequence of interneuronal crosstalk could avoid electromagnetic neuronal noises. At the nerve terminal, neurotransmitters are present within 35-50 nm synaptic vesicles that release neurotransmitters that dock and fuse at the base of specialized 10—15 nm cup-shaped lipoproteins. These porosomes range from 15 nm in neurons, astrocytes to 100—180 nm in endocrine and exocrine cells. In striatal neurons adenylyl cyclase (AC) coupled via 7TM receptors via stimulatory or inhibitory receptors (Rs and Ri) on G protein phosphorylation. A dopamine-(DA)-dependent cAMP/PKA interactions with acetylcholine and adenosine signals for DA transients to carry reward-related signals in learning reinforcement. The enthalpies of AC-H-bonds breakdown of intermediates coordinated by Mg2+ and bending and sliding when calmodulin release of Ca2+ to coordinative into hydrophobic box, and release of dimers in the up-hill thermodynamics cycling AMP into cAMP, creating molecular transitions capable to participate in meaningful encoding signals coordinative stages. The Mg-cAMP response element binding (CREB) protein by insertion for DNA H-bond breakdown unzipping into three strands and transcription cycle turnover by coupling to H-bond donor water cluster.
Category: Quantitative Biology