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| viXra.org > Biochemistry > 2310 |
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[2] viXra:2310.0068 [pdf] submitted on 2023-10-13 03:06:12
Authors: Alfred Bennun
Comments: 47 Pages. 23 figures
The development from a hormonal memory based on the hypothalamic-pituitary-adrenal (HTPA) axis is constituted by a complex set of direct influences and feedback interactions, among the components of an adrenal neuroendocrine system that during human nurturing allows hormonal communication, integrating a newborn with his family. The brain hypothalamus functions to regulate the anterior pituitary to develop hormonal (fully emotional) communication that precedes the stage of language development. A pure emotional language constitutes an unconscious, a barrier to self-cognition on the own personality dynamics. This one could be potentiated by Doppler analysis of vector neuronal emotional childhood association to the adult stage to constitute new psyche connectomes. These ones are accessible to psychoanalytic techniques that focus on the study of the psyche, and treatment by using free association to allow healing. Dehydroepiandrosterone (DHEA), an endogenous corticoid (internally produced), is the most abundant circulating steroid in humans, which is not required as vitamins, which are only available from food. DHEA is a prohormone derived from cholesterol and pregnenolone that is a precursor of mineralcorticoids (aldosterone, etc.), glucocorticoids (cortisol, etc.) and testosterone and estradiol. Usually a clinical treatment to supplement the level of testosterone or estradiol will produce the desired immediate effect, but thereafter reduce the physiological natural production, as expression of a negative feedback. DHEA might prove to have benefits in treating people diagnosed with certain conditions, such as adrenal insufficiency and lupus. Hence, these ones will respond to a physiological regulation through the attractive sexual pathways. Adolescence increases DHEA levels declining by 75-90% by the time humans hit 75-80 years old associated with a loss of function and increased risk for disease. It impacts quality of life and longevity. DHEA has become a popular anti-aging supplement. A 12 years study of old men found that an increase of 100 μg/dL of DHEA-sulfate solution injected in blood showed a 36% reduced risk of death.
Category: Biochemistry
[1] viXra:2310.0035 [pdf] submitted on 2023-10-07 15:57:16
Authors: Adam Mohib, Kiran Abraham, Karan Ramesh Urs, Tamilchezhiyan Kalidass, Rishi Chandrasekaran, Rayna Jindal, Vivitsa Labh, Mostafa Khan
Comments: 7 Pages.
Type 2 diabetes, often referred to as T2D, is a widespread health condition. This study focuses on the specific genetic variation in a single nucleotide poly- morphism (SNP) rs7903146 in the gene TCF7L2 and its potential association with T2D. We examined DNA samples from Bangladeshi individuals to see whether the genetic variant rs7903146 is associated with T2D in this community. We discovered that the CC variant of rs7903146 was extremely prevalent, appearing in all of the samples from people without T2D and in the majority of the samples from people with T2D out of the 38 sequences they looked at (16 from people without T2D and 22 from people with T2D). In a tiny proportion of T2D patients, there was also a less prevalent variant called CT. Surprisingly, the Bangladeshi population in this study did not show a clear association be- tween rs7903146 and T2D. This counters what several earlier investigations have found. This opens the door for more future research to completely comprehend the genetic and environmental causes of T2D to build preventative treatments for this quickly increasing global health problem.
Category: Biochemistry
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