Biochemistry

Preproinsulin Molecule and Numbering of the Twenty Proteinogenic Amino Acids

Authors: Jean-Yves Boulay
Comments: 16 Pages.

The amino acid sequence of the 110-amino acid preproinsulin, the initial product of the translation of insulin mRNA, is in close dependence with the numbering of the twenty proteinogenic amino acids. Recalling here this new concept of amino acid numbering, classification deduced from their genetic translation, it is demonstrated that the orders of occurrence of the various preproinsulin amino acid, both direct and inverse sequence, are organized in numerous ratios of exact value 3/2. This, according to the new amino acid numbering concept. The degree of abundance of these amino acids in this initial single-chain molecule reveals same numerical rational phenomena.
Category: Biochemistry