Authors: Garbapu Suresh, Ratnakaram Venkata Nadh, Navuluri Srinivasu, Durgaprasad Yennity
A new and efficient synthetic route for dual-Src/Abl kinase inhibitor dasatinib (Sprycel®), an anticancer drug, is described. This commercially viable process yields dasatinib monohydrate free of potential impurities with consistent yield of 68% in route A and 61% in route B with HPLC purity >99.80% over four stages.
Comments: 12 Pages. OK
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[v1] 2019-05-19 02:59:03
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