Authors: Yara Islam Abd El Aziz, Rawda Waleed Khafaga
Autism Spectrum disorder (ASD) is a developmental disorder in which symptoms generally appears in the first two years of toddler's life. It's about three types or similar conditions including Asperger syndrome, Autism and PDD-NOS. ASD affects the person's social interaction, communication and behavior. Although a diagnosis can sometimes be made after 3 years of appearing the symptoms. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), a guide created by the American Psychiatric Association used to diagnose mental disorders, people with ASD have: •Difficulty with communication and interaction with other people •Restricted interests and repetitive behaviors •Symptoms that hurt the person’s ability to function properly in school, work, and other areas of life. By knowing these symptoms it's estimated that there is about 1 of each 100 people in UK has ASD. There is no accurate cure for the ASD that causes the whole recovery. Almost, some treatments that decrease the worth of the disorder and some physiological therapies as speech and language therapy, occupational therapy, educational support, plus a number of other interventions are available to help children and parents to let them more sociable or to make them interact normally with people. Also, there is a treatment that called "Surmain" was invent to help people suffers from human sleeping sickness that helps in treatment of ASD as the mechanism of existing ASD is , Stressed cells emit ATP and other molecules made by mitochondria into the extracellular space through channels in the cell membrane. Extracellular ATP (eATP) is an ancient danger signal. It is called a "damage associated molecular pattern" or DAMP. When too much eATP is emitted, it joins purinergic receptors and activates the CDR. So, surmain blocks the binding of eATP and eADP to these receptors and sends the cellular equivalent of the "all's clear" or safety signal. But, there's a problem with this cure as it causes rash. So, after long researches we found that there's a compound of histamine has a central role as a mediator of itching. It causes the rash after taking the Surmain. So, we concluded that we could use a cure to resist rash which doesn't react or causing any bad effects
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