Determination of Mianserine Using Fe3+-Phenanthroline by Visible Spectrophotometry

Authors: Giri Prasad Gorumutchu, Venkata Nadh Ratnakaram

Mianserin is used as an antidepressant medication. A visible spectrophotometric method was developed for determination of Mianserine present in bulk and tablet formulation. The basis of the proposed method is formation of a chromophore (of λ max 484 nm) in presence of Fe3+-Phenanthroline. Optimization of reaction conditions was carried out to get highly sensitive and stable colored complex. The proposed method does not require a pre-treatment process. The method has the advantage of simple, reproducible, selective and sensitive. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (1 – 6 μg mL-1). The % recovery values falls in 98.00 – 99.66 range. As per the existing guidelines of ICH, various parameters of the method were tested for validation. %RSD results of both precision studies were observed in the range 0.181 – 0.530 and -0.135 – 0.408 respectively, indicating the satisfactory precision of the method. Low values of R.S.D. (< 2 %) were observed indicating that the proposed method is reproducible, accurate and precise. The proposed method can be used in routine analysis of Mianserine (bulk drug and pharmaceutical dosage forms) in quality control laboratories, as an alternative to the methods which require expensive instruments.

Comments: 4 Pages. OK

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[v1] 2019-05-19 02:13:33

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