Simple and Validated Ultraviolet Spectrophotometric Method for the Estimation of Lurasidone in Bulk Form

Authors: Muvvala S Sudhir, Ratnakaram V Nadh

A simple, sensitive, precise, accurate and economical spectrophotometric method of analysis for lurasidone in bulk form was developed and validated. The method employed acetonitrile as solvent and the drug shows maximum absorbance at 263 nm. The absorbance was found to increase linearly with increasing concentration of lurasidone, which is corroborated by the calculated correlation coefficient value (r2 = 0.999). The linear regression analysis data for the calibration plot showed good linear relationship with in the concentration range of 10 – 60 μg/ml. The limit of detection and limit of quantitation were found to be 1.25316 μg/ ml and 3.797468 μg /ml respectively. This method was tested and validated for various parameters according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (R.S.D. < 2 %).

Comments: 9 Pages. OK

Download: PDF

Submission history

[v1] 2019-05-19 05:50:15

Unique-IP document downloads: 8 times is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus