Physics of Biology


Protein Error-Free Nanostructures

Authors: George Rajna

Using a DNA-binding protein called RecA as a kind of nanoscale rebar, or reinforcing bar, to support the floppy DNA scaffolding, researchers at the National Institute of Standards and Technology (NIST) have constructed several of the largest rectangular, linear and other shapes ever assembled from DNA. [25] The technique, dubbed DNA origami, enabled scientists to create self-assembling DNA structures that could carry any specified pattern, such as a 100-nanometer-wide smiley face. [24] For the past few decades, scientists have been inspired by the blueprint of life, DNA, as the shape of things to come for nanotechnology. [23] The new study involves innovations in the field of DNA origami, which, as the name implies, uses nucleic acids like DNA and RNA to fold and self-assemble into complex forms. [22] In a new study that supports the trend of DNA-based information carriers, scientists have engineered a DNA navigator system that can perform single-molecule, parallel, depth-first search operations on a two-dimensional origami platform. [21] In new research, Hao Yan of Arizona State University and his colleagues describe an innovative DNA HYPERLINK "" walker, capable of rapidly traversing a prepared track. [20] Just like any long polymer chain, DNA tends to form knots. Using technology that allows them to stretch DNA molecules and image the behavior of these knots, MIT researchers have discovered, for the first time, the factors that determine whether a knot moves along the strand or "jams" in place. [19] Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure. [18] An LMU team now reveals the inner workings of a molecular motor made of proteins which packs and unpacks DNA. [17] Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. [16]

Comments: 51 Pages.

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[v1] 2018-11-17 08:27:00

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