The Antithrombotic Activity of Corilagin Purified from Korean Herb-Phyllanthus Ussuriensis

Authors: Kum Chol Ri

Plasminogen activator inhibitor-1(PAI-1) is a main negative regulator of the fibrinolytic system. In animal studies, inhibition of PAI-1 activity prevents arterial and venous thrombosis, indicating that PAI-1 inhibitors may be used as a new class of antithrombotics. In this study, we revealed that corilagin which purified from Korean herb, Phyllanthus ussuriensis, inhibited plasma PAI-1 and increased the activity of t-PA in vitro and in vivo. We then observed that when injected more than 6mg/kg of corilain into the rat electrically stimulated carotid artery thrombosis rat, the rethrombosis ratio was lower than 28.6%, and it was much lower than when 20000IU/kg of urokinase was injected. At the end we found out that corilagin remarkably decreased the content of plasma fibrin in the thrombosis rat and the decrease at dose of more than 6mg/kg was about 4.4 fold than the control. Our data show that corilagin is a new class of small molecule PAI-1 inhibitors with anti-thrombotic potential and has great prospect as thrombosis therapeutic drug.

Comments: 4 Pages.

Download: PDF

Submission history

[v1] 2018-11-11 05:13:26

Unique-IP document downloads: 30 times is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus