Fabrication of biocompatible electrodes for investigation of catecholamines is a known challenge. In this work, methionine was chosen as a modifier for fabrication of a biocompatible carbon paste electrode by electropolymerization through cyclic voltammetry. The electrochemical behavior of the polymethionine modified carbon paste electrode was characterized by cyclic voltammetry for simultaneous determination of dopamine (DA) and uric acid (UA) in a phosphate buffer solution at pH 7.0. In the absence of an amino acid methionine layer, the bare carbon paste electrode exhibits a rather poor voltammetric signals in DA and UA in the binary mixture with oxidation potentials of DA and UA overlapping with each other. The polymethionine modified carbon paste electrode exhibits good catalytic activity with noticeably different oxidation potentials of DA and UA. The experimental results closely agree with the theoretical prediction based on Fukui function complementary to the simulated electrostatic potential maps.
Comments: 25 Pages. Accepted for publication in International Journal of Electrochemistry
[v1] 2018-11-01 23:06:19
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