Discussing Modern Updated Criteria for Judging Autoimmune Disease

Authors: Wan-Chung Hu

Witebsky’s criteria for autoimmune diseases were used for decades since 1957. His postulates are: 1. Direct demonstration of free circulating antibodies active at body temperature 2. Recognition of the specific antigen 3. Production of antibodies against same antigen in experimental animals 4. Experimental animal demonstrates same tissue changes in human. More updated and applicable criteria for autoimmune disorders are required due to recent advance in molecular immunology. Here, I propose new criteria. Possible criteria is HLA association. Probable criteria is HLA association plus TH subtype restriction without pathogen. Definite criteria is experimentally reproducible by autoantibody or self reactive T cell transfer. Optional criteria is Clinical or pathology clues. This new criteria is more practical. It should help to explore the actual disease pathophysiology and lead to better diagnosis and treatment strategies.

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[v1] 2018-03-19 00:20:16

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