Biochemistry

   

Development and Evaluation of Fast Disintegrating Tablets of Ondansetron with Natural and Synthetic SuperDisintegrating Agents

Authors: Latha Uppala1, Palle Pranusha

Ondansetron a widely prescribed anti-ulcer drug belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor solubility and dissolution rate and having high permeation rate. In the present work, oral disintegrating tablets of Ondansetron were developed with a view to enhance the patient compliance and provide quick onset of action. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an anti-emetic (to treat nausea and vomiting). It affects both peripheral and central nerves. Ondansetron reduces the action of the vagus nerve, which deactivate the vomiting centre, and also block serotonin receptors in the chemoreceptor trigger zone. It has slight effect on vomiting caused by motion sickness, since drug is highly bitter. The drug solid dispersed coated granules showed no bitterness in the taste. Oral disintegrating tablets prepared by direct compression method using super disintegrants like cross povidone, cross carmellose sodium, sodium starch glycolate, in different concentrations and evaluated for the pre-compression parameters such as bulk density, compressibility and angle of repose. The arranged batches of tablets were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time and invitro dissolution profile and found satisfactory. Aim: The aim of the present study is to formulate and evaluate fast disintegrating tablets of Ondansetron by direct compression method employing super disintegrating agents. The objective of present study: • The purpose of this research was to mask the strongly bitter taste of Ondansetron HCL and to formulate a rapid - disintegrating tablet. • To formulate an orally disintegrating tablet so that it can be administered to paediatric and geriatric patients.

Comments: 7 Pages.

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[v1] 2017-08-23 05:09:58

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