Physics of Biology

   

Bioimaging Technique

Authors: George Rajna

A new approach to optical imaging makes it possible to quickly and economically monitor multiple molecular interactions in a large area of living tissue—such as an organ or a small animal; technology that could have applications in medical diagnosis, guided surgery, or pre-clinical drug testing. [20] Chemists at ITbM, Nagoya University have developed a super-photostable fluorescent dye called PhoxBright 430 (PB430) to visualize cellular ultra-structure by super-resolution microscopy. [19] Dipole orientation provides new dimension in super-resolution microscopy [18] Fluorescence is an incredibly useful tool for experimental biology and it just got easier to tap into, thanks to the work of a group of University of Chicago researchers. [17] Molecules that change colour can be used to follow in real-time how bacteria form a protective biofilm around themselves. This new method, which has been developed in collaboration between researchers at Linköping University and Karolinska Institutet in Sweden, may in the future become significant both in medical care and the food industry, where bacterial biofilms are a problem. [16] Researchers led by Carnegie Mellon University physicist Markus Deserno and University of Konstanz (Germany) chemist Christine Peter have developed a computer simulation that crushes viral capsids. By allowing researchers to see how the tough shells break apart, the simulation provides a computational window for looking at how viruses and proteins assemble. [15] IBM scientists have developed a new lab-on-a-chip technology that can, for the first time, separate biological particles at the nanoscale and could enable physicians to detect diseases such as cancer before symptoms appear. [14] Scientists work toward storing digital information in DNA. [13] Leiden theoretical physicists have proven that DNA mechanics, in addition to genetic information in DNA, determines who we are. Helmut Schiessel and his group simulated many DNA sequences and found a correlation between mechanical cues and the way DNA is folded. They have published their results in PLoS One. [12]

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[v1] 2017-08-19 03:21:54

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