Quantitative Biology


Computational Genetic Chemistry

Authors: James Bonnar

In this book we discuss the technical and non-technical reasons science has been unable to find cures for heritable diseases, despite the exponential increase in knowledge of disease mechanisms we currently witness. New directions in scientific research and protocols are suggested that may help bring about actual cures for genetic diseases through pharmacological gene therapy. A computational paradigm, called the omega algorithm, is developed, implemented and applied to find compounds that could potentially correct the delta F508 mutation responsible for cystic fibrosis. Links to downloadable files, including an extensive chemical reaction database, are given in an appendix to assist the reader with further studies.

Comments: 76 Pages.

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Submission history

[v1] 2016-10-17 07:15:18

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