Authors: Ilija Barukčić
Comments: 29 Pages. (C) Ilija Barukčić, 2019, Jever, Germany. All rights reserved.
Objective: To date, it is quite common to claim that some patient groups benefit from statin therapy in both primary and secondary prevention of cardiovascular disease while equally the use of higher-intensity statin therapies is emphasized. In this Review, the efficacy of statin therapy in light of the study data available is explored.
Methods: All in all, 40 studies with a sample size of n = 88388 were re-analyzed. The exclusion relationship was used to test the null-hypothesis: a certain statin does exclude death due to any cause. The causal relationship k was used to test the data for causality. The level of significance was set to Alpha = 0,05.
Results: The data of the studies reanalyzed provide convincing evidence that statins unfortunately do not exclude death due to any cause. An immediate statin therapy discontinuation should be considered.
Conclusions: Overwhelming evidence suggests that the risk potential harmful effects of statin therapy far outweigh any real or perceived benefit.
Keywords: Statins, death, causal relationship.