Quantitative Biology

1308 Submissions

[1] viXra:1308.0135 [pdf] replaced on 2013-10-07 00:48:19

The Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1-Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell di

Authors: Peisheng Shi, Hai Zhang, Zhiguo Zhu
Comments: 17 Pages.

In this article, we use system dynamical model (base on a set of nonlinear differential equations) and stochastic process model (Master equations of elementary reaction) to simulate the T helper cell differentiation (including Th1-Th2-Th17-Treg), especially the Th1-Th2 differentiations signaling network. We draw a conclusion that the critical trigger factor of naive T helper cells differentiation is the concentration of differentiation induced cytokines. We also compare the result of these two models as well as discussed the advantage and disadvantage of them.
Category: Quantitative Biology