1802 Submissions

[5] viXra:1802.0360 [pdf] submitted on 2018-02-26 12:23:58

The Golden Ratio, the Principle of Construction of Atoms

Authors: Raji Heyrovska
Comments: 3 pages

Exactly today fifteen years ago, the author arrived at the unique result that the ground state Bohr radius of the hydrogen atom is divided into two parts pertaining to the electron and proton, the ratio of which was amazingly a constant. This constant turned out to be the Golden ratio, a mathematical constant, known from ancient times to appear in many spontaneous creations of Nature, big and small. Further work showed that the interatomic distances in alkali metals and halogens are divided exactly into their cationic and anionic radii by the Golden ratio, the sums of which accounted precisely for the interionic distances in alkali halides. This cascaded over the years into the additivity rule of atomic and or ionic radii in the structures of small as well as large molecules. This is summarized in this short paper.
Category: Chemistry

[4] viXra:1802.0308 [pdf] submitted on 2018-02-21 19:39:11

Evaluation of Activation Energies on As(v) Sorption Onto Magnetic Separable Poly P-Phenylenediamine-Thiourea-Formaldehyde Polymer [J. Hazard. Mater. 342 (2018) 335–346]

Authors: Yong-Son Hong, Sok-Bong Pak, Yong-Uk Ryu, Sok-Jin Ri, Jong-Sob Kim, Jong-Hyok Yang
Comments: 8 Pages.

In this work, the As(V) sorption onto magnetic separable poly p-phenylenediamine-thiourea-formaldehyde polymer (MpPDTF) published by Elwakeel and Al-Bogami was reevaluated using deactivation kinetics model (DKM). As the result, the reaction order and the activation energies were newly calculated.
Category: Chemistry

[3] viXra:1802.0287 [pdf] replaced on 2018-04-04 07:30:39

Kinetic Reevaluation on Adsorption of Benzothiophene Sulfone Over Clay Mineral Adsorbents in the Frame of Oxidative Desulfurization

Authors: Hong-Chol Jin, Yong-Son Hong
Comments: 4 Pages.

In this communication, the adsorption of benzothiophene sulfone (BTO) over clay mineral adsorbents [Fuel 205 (2017) 153–160] was reevaluated using deactivation kinetics model (DKM). As the result, the reaction order and the activation energies were newly calculated. Keywords: Adsorption, Kinetics, Modeling
Category: Chemistry

[2] viXra:1802.0089 [pdf] submitted on 2018-02-08 09:24:00

A Demonstration of an Analytical Method Development and Validation Process Using the Identification and Assay of Ondansetron Hydrochloride Dihydrate in Ondansetron Hydrochloride 4mg/5ml Syrup (Nausetron) by High Performance Liquid Chromatography.

Authors: Sulaiman Mujoobe
Comments: 36 Pages. CC-BY LICENCE: Anyone can share, reuse, remix, or adapt this material for any purpose, providing the original authors are credited and cited.

ABSTRACT: The main purpose of this paper is to attempt to give a detailed step by step explanation of how data is collected and statistically treated during an analytical method development and validation protocol for Quality Control of Pharmaceutics. In most cases, modification to a given manufacturing process, formulation or synthetic pathway during a drug development program may necessitate changes to existing analytic methods. As a consequence, this change may require additional transfer and or validation studies. Effective method development in a pharmaceutical industry is aimed at ensuring that analytical methods meet the objectives required at each stage of drug development using the least resources available of which developmental time and cost are the main targets. Method validation involves demonstrating that these methods are suitable for their intended use as required by regulatory agencies. Method transfer is the formal process of assessing the suitability of methods in another laboratory. These studies involve numerous steps taken, according to a given Standard Operating Procedure (SOP) to collect data. Data analysis usually encompasses confusing mathematical manipulations that may require extensive knowledge of statistics. Although most papers and articles on method development and validation indicate how data is collected, very few give the final acceptance result and show how it was calculated. This paper therefore fills this gap by illustrating, following a hypothetical Standard Operating Procedure: MUJ-256-B dated 16th July 2015 from a hypothetical JBXY Pharmaceuticals, how to develop and validate a method to identify and quantitatively determine the concentration of the active pharmaceutical ingredient; (±) 1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl]-4H-carbazol-4 one, monohydrochloride, dihydrate (Ondansetron hydrochloride dihydrate) in Ondansetron hydrochloride 4mg/5ml Syrup (Nausetron) by Reversed-Phase High Performance Liquid Chromatography. Keywords: Acceptance Criteria, Hypothesis Testing, International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; Method Transfer; Ondansetron; Pharmaceutical; Statistics; Reversed-Phase; Biostatistics; Statistical Treatment; Quality Assurance; Quality Control.
Category: Chemistry

[1] viXra:1802.0060 [pdf] submitted on 2018-02-05 12:02:49

Atomic and Ionic Radii in the Structures of Inorganic, Organic and Biological Molecules: Reference Papers with Data and Figures

Authors: Raji Heyrovska
Comments: 15 pages

Presented here is a collection of papers by the author with reference data on atomic and ionic radii which account for the chemical bonds in inorganic, organic and biological molecules, and relevant figures.
Category: Chemistry