Authors: Raji Heyrovska
Comments: Pages. 5 Figures, Table 1. In the acknowledgement, Tim Gonen should read Tamir Gonen.
The recent new rapid technique of determining structures of molecules by CryoEM Method microED techniques by Gonen et al, aroused the interest to compare the reported bond lengths for acetaminophen with the additivity of adajacent atomic radii rule. The latter was found by the author to explain the bond lengths in many small as well as large molecules. The bond distances obtained by conventional methods and those found by Grunen et al by electron diffraction agree well with the additivity rule, whereas those by the Gonen group seem slightly smaller. A possible reason is discussed here.
Authors: Kum Chol Ri
Comments: 4 Pages.
Plasminogen activator inhibitor-1(PAI-1) is a main negative regulator of the fibrinolytic system. In animal studies, inhibition of PAI-1 activity prevents arterial and venous thrombosis, indicating that PAI-1 inhibitors may be used as a new class of antithrombotics. In this study, we revealed that corilagin which purified from Korean herb, Phyllanthus ussuriensis, inhibited plasma PAI-1 and increased the activity of t-PA in vitro and in vivo. We then observed that when injected more than 6mg/kg of corilain into the rat electrically stimulated carotid artery thrombosis rat, the rethrombosis ratio was lower than 28.6%, and it was much lower than when 20000IU/kg of urokinase was injected. At the end we found out that corilagin remarkably decreased the content of plasma fibrin in the thrombosis rat and the decrease at dose of more than 6mg/kg was about 4.4 fold than the control. Our data show that corilagin is a new class of small molecule PAI-1 inhibitors with anti-thrombotic potential and has great prospect as thrombosis therapeutic drug.