1804 Submissions

[6] viXra:1804.0489 [pdf] submitted on 2018-04-29 08:56:25

Smarter Drugs

Authors: George Rajna
Comments: 31 Pages.

A new method has been developed to make drugs 'smarter' using nanotechnology so they will be more effective at reaching their target. [19] It's called gene editing, and University of Alberta researchers have just published a game-changing study that promises to bring the technology much closer to therapeutic reality. [18] An LMU team now reveals the inner workings of a molecular motor made of proteins which packs and unpacks DNA. [17] Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. [16] What makes particles self-assemble into complex biological structures? [15] Scientists from Moscow State University (MSU) working with an international team of researchers have identified the structure of one of the key regions of telomerase—a so-called "cellular immortality" ribonucleoprotein. [14] Researchers from Tokyo Metropolitan University used a light-sensitive iridium-palladium catalyst to make "sequential" polymers, using visible light to change how building blocks are combined into polymer chains. [13] Researchers have fused living and non-living cells for the first time in a way that allows them to work together, paving the way for new applications. [12] UZH researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. [11] Dr Martin Sweatman from the University of Edinburgh's School of Engineering has discovered a simple physical principle that might explain how life started on Earth. [10] Nearly 75 years ago, Nobel Prize-winning physicist Erwin Schrödinger wondered if the mysterious world of quantum mechanics played a role in biology. A recent finding by Northwestern University's Prem Kumar adds further evidence that the answer might be yes. [9]
Category: Biochemistry

[5] viXra:1804.0450 [pdf] submitted on 2018-04-28 07:43:37

Nuclease Activity of the DNA Polymerases: an Evasion of Microscopic Reversibility Leading to Fidelity in Excess of Kinetic Control Levels

Authors: Sosale Chandrasekhar
Comments: 8 Pages.

The exonuclease and endonuclease activities of the DNA polymerases, which extend their proof-reading capabilities and maintain high fidelity in the replication process, apparently conflict with the principle of microscopic reversibility. However, deeper mechanistic analysis of the reaction leads to fascinating insights into the kinetic and thermodynamic effects controlling the replication of the primary genetic material. Thus, nucleotide addition and excision apparently involve different pathways, although violation of microscopic reversibility is avoided as the overall reaction does not reach equilibrium. Intriguingly, however, this allows the fidelity levels to exceed those expected from simple kinetic control.
Category: Biochemistry

[4] viXra:1804.0361 [pdf] submitted on 2018-04-25 00:02:28

Effect of Biofield Energized Vitamin D3 on Bone Health in MG-63 Cell-Line

Authors: Faith Ann Pyka, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Sambhu Charan Mondal, Snehasis Jana
Comments: 9 Pages.

The objective of current research work was to evaluate the potential of Consciousness Energy Healing-based vitamin D3 and DMEM medium on bone health parameters such as alkaline phosphatase (ALP), collagen, and bone mineralization in human bone osteosarcoma cells (MG-63). The test items like vitamin D3 and DMEM were divided into two parts. One part of each sample was received the Biofield Energy Treatment by Faith Ann Pyka and those samples were denoted as the Biofield Energy Treated (BT) samples, while the other parts of each sample were referred as the untreated test items (UT). The MTT cell viability assay revealed that the test samples were found as safe in the tested concentrations. The level of ALP was significantly increased by 191.45% in the BT-DMEM + UT-Test item (UT-TI) group at 1 µg/mL compared to the UT-DMEM + UT-TI group. Moreover, ALP level was significantly increased by 144.89% and 226.75% in the UT-DMEM + BT-TI and BT-DMEM + BT-TI groups, respectively at 50 µg/mL compared to the untreated group. Further, collagen level was significantly increased by 98.15%, 80.54%, and 49.98% in the UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI groups, respectively at 10 µg/mL compared to the untreated group. Additionally, at 50 µg/mL level of collagen was significantly increased by 129.73%, 189.16%, and 94.60% in the UT-DMEM + BT-Test item, BT-DMEM + UT-Test item, and BT-DMEM + BT-Test item groups, respectively with respect to the untreated group. Apart from this, the percent of bone mineralization was distinctly enhanced by 283.74%, 27.91%, and 118.02% in the UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI groups, respectively at 50 µg/mL compared to the untreated group. Moreover, the percentage of bone mineralization was significantly increased by 265.92%, 231.82%, and 158.2% in the UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI groups, respectively at 100 µg/mL compared to the untreated group. Altogether, the Biofield Energy Treated vitamin D3 was significantly improved the bone health parameters and it could be an alternative approach for nutraceutical supplement to combat vitamin D3 deficiency and able to fight against various bone-related disorders including rickets, low bone density, osteomalacia, bone and joint pain, bone fractures, osteoporosis, osteoma, osteogenesis imperfecta, Paget’s disease, deformed bones, chondrodystrophia fetalis, stress management and prevention, autoimmune and inflammatory diseases, and anti-aging by improving overall health.
Category: Biochemistry

[3] viXra:1804.0279 [pdf] submitted on 2018-04-19 10:07:17

Reasons for High Life Expectancy at Birth with Males in Hambantota District in Sri Lanka

Authors: Imesha Rashmini Rathnayaka1, Nivethika Sivakumaran1
Comments: 9 Pages.

Introduction:It has been proven twice that the Hambantota District has the highest life expectancy in male population. This study focused to find and identify reasons for Hambantota District people to have high life expectancy at birth. Methodology: Research was carried out in both qualitative and quantitative phases in five MOH (Medical Health Officer) divisions in Hambantota District. Study focused on 3 age categories, 55-65 Years, 66-75 Years, and above 76 Years. Main objectives and key information areas are Life Style and Social Behaviors, Food Consumption and Diet, Familial Trait and Physical and Mental Health. Results: Majority of the male population have educated up to grade 5 and most are engaged in the agriculture while others engaged in fishery and self-employment etc. Almost everyone reachestheir workplaces by foot or by bicycle. Many of them work less than six hours. They spend their free time with their family members and watch TV. Most of them do not consume alcohol and smoke. Almost everyone take part in social activities. Majority eat red rice for all three meals. Almost everyone eats fish every day. They have a high salt intake. Their parents and ancestors have also have had a high life expectancy. Only a minority suffer from chronic illnesses. They all have a good physical and mental health condition. They spend happy and relaxed lifestyle. Conclusion: Healthy diet, low alcohols consumption and smoking, high iodine intake, physical activeness and their social well being effect for high life expectancy within the male population of selected five MOH divisions in Hambantota District. They have a free and happy life. Genetics of these people also may contribute for high life expectancy. Abundance of neem trees in this area also may effect on their high life expectancy.
Category: Biochemistry

[2] viXra:1804.0209 [pdf] submitted on 2018-04-17 02:02:00

Did the Emergence of Blood Groups Weed Out Cannibalism? a New Take on a Persistent Conundrum

Authors: Sosale Chandrasekhar
Comments: 6 Pages.

It is proposed that the emergence of different blood groups – whether in humanoids or their predecessors – served as a strong deterrent to the mixing of blood from different individuals. Cannibalism is the most likely activity in which such mixing would have been inevitable. In fact, the immunological significance of the blood groups may be overblown, as a correspondence between antigen and antibody is not always apparent in them. These conclusions also raise intriguing questions about the consumption of animal meats and blood by humans, with interesting implications for currently held views on diet and disease.
Category: Biochemistry

[1] viXra:1804.0075 [pdf] submitted on 2018-04-06 01:19:10

Determination of the Fatty Acids of Hibiscus Manihot Seed Oil by GC-MS

Authors: Ri Hyon Il, Yang Zheng Hyok, Son Kwen Il, Ri Chel Jin
Comments: 8 Pages. analysis

The oil was extracted from Hibiscus manihot seed using Soxhlet extraction method, petroleum ethersoak method..The fatty acid compositions of seed oil were analyzed by GC/MS and Gas Chromatographic conditionwas optimized. The results showed that the content of linoleic acid, oleic acid and palmitoleic acid were 58.36 %, 1.66 % and21.95 % respectively and unsaturated fatty acids were 75.56 %.
Category: Biochemistry