Authors: Ilija Barukčić
Objective: To date, it is quite common to claim that some patient groups benefit from statin therapy in both primary and secondary prevention of cardiovascular disease while equally the use of higher-intensity statin therapies is emphasized. In this Review, the efficacy of statin therapy in light of the study data available is explored. Methods: All in all, 40 studies with a sample size of n = 88388 were re-analyzed. The exclusion relationship was used to test the null-hypothesis: a certain statin does exclude death due to any cause. The causal relationship k was used to test the data for causality. The level of significance was set to Alpha = 0,05. Results: The data of the studies reanalyzed provide convincing evidence that statins unfortunately do not exclude death due to any cause. An immediate statin therapy discontinuation should be considered. Conclusions: Overwhelming evidence suggests that the risk potential harmful effects of statin therapy far outweigh any real or perceived benefit. Keywords: Statins, death, causal relationship. Barukcic@t-online.de
Comments: 29 Pages. (C) Ilija Barukčić, 2019, Jever, Germany. All rights reserved.
[v1] 2019-12-06 12:00:41
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