Biochemistry

   

Human Gene Jak2 is a Promising Model for Studying Regulation of Genes Expression by a Mechanism of Wave Collapse on the DNA

Authors: Denis Semyonov

In human gene JAK2 the fragment with regulatory structure GTATGTGT is repeated more than 10 times. The mutation V617F (G→T) in this site belonging to an 14 exon, is associated with so called myeloproliferative diseases. E.g., if the mutation leads to violation of the purine-pyrimidine alternation, the respective site loses the ability of the rearrangement and becomes non-regulatory. Thus, contribution of the mutation to oncogenesis can relate to a disturbance of the mechanism of regulation of the gene expression.

Comments: 3 Pages.

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Submission history

[v1] 2019-10-02 10:35:36

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