Authors: Ilija Barukčić
Objective. Under certain circumstances, the results of multiple investigations – particularly, rigorously-designed trials, can be summarized by systematic reviews and meta-analyses. However, the results of properly conducted meta-analyses can but need not be stronger than single investigations, if (publication) bias is not considered to a necessary extent. Methods. In assessing the significance of publication bias due to study design simple to handle statistical measures for quantifying publication bias are developed and discussed which can be used as a characteristic of a meta-analysis. In addition, these measures may permit comparisons of publication biases between different meta-analyses. Results. Various properties and the performance of the new measures of publication bias are studied and illustrated using simulations and clearly described thought experiments. As a result, individual studies can be reviewed with a higher degree of certainty. Conclusions. Publication bias due to study design is a serious problem in scientific research, which can affect the validity and generalization of conclusions. The index of unfairness and the index of independence are of use to quantify publication bias and to improve the quality of systematic reviews and meta-analyses. Keywords: study design, study type, measuring technique, publication bias
Comments: 24 pages. Copyright © 2019 by Ilija Barukčić, Jever, Germany. All rights reserved. Published by:
[v1] 2019-07-24 05:53:26
Unique-IP document downloads: 74 times
Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.