Authors: Ilija Barukčić
Aim Rheumatoid arthritis (RA) is associated with increased risk of coronary artery disease (CAD). Studies reported that anti-rheumatic drug usage is associated with decreased risk of CAD events in RA patients. This study was conducted to investigate the effect of some anti-inflammatory drugs (etanercept, leflunomide, etoricoxib) on the development of CAD events among patients with RA using anti-rheumatic drug in comparison with nonusers. Methods A systematic review of CAD events in RA patients was performed who used leflunomide, etanercept and etoricoxib and was compared with RA patients who don’t use these drugs. The exclusion relationship and the causal relationship k were used to test the significance of the result. A p-value of < 0.05 was treated as significant. Results Among RA patients, use of leflunomide (p (EXCL) =0,999022483; X2 (EXCL) = 0,06; k = -0,03888389; p-value ( k | HGD) =0,00037588), etanercept and etoricoxib was associated with significantly decreased incidence of CAD. The use leflunomide, etanercept and etoricoxib excludes cardiac events in RA patients. Conclusion The results of study provide further support for the infectious hypothesis of atherosclerosis. Key words: atherosclerosis, rheumatoid arthritis, therapy, causal relationship
Comments: 16 pages. Copyright © 2019 by Ilija Barukčić, Jever, Germany. All rights reserved. Published by:
[v1] 2019-05-29 00:56:35
Unique-IP document downloads: 30 times
Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.