Determination of Mianserin Using Tropaeolin-Ooo by Ion Pair Formation

Authors: Giri Prasad Gorumutchu1, Venkata Nadh Ratnakaram

Objective: The present study was aimed at the development of a simple visible spectrophotometric method for the assay of mianserin, a drug used for the treatment of depression. Methods: The method was developed using tropaeolin-ooo (TPooo) as an ion associative complex forming a chromophore. Developed the chromophore by sequential mixing of aqueous solutions of mianserin, hydrochloric acid, and TPooo. Chromophore was extracted into an organic solvent (chloroform) and absorbance values of organic layers were measured. As per the existing guidelines of an international conference on harmonization (ICH), various parameters of the method were tested for validation. Results: At the optimized reaction conditions, the formed chromophore (λ max Conclusion: Due to lack of pre-treatment process for this method, it was simple. All the tested parameters of the method were validated as per ICH guidelines.

Comments: 6 Pages. OK

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[v1] 2019-05-19 02:16:43

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