Authors: George Rajna
A previously unknown autoimmune muscle disease involving sudden onset of debilitating muscle pain and weakness has been identified by researchers at Washington University School of Medicine in St. Louis.  The discovery that protein therapeutics can hijack the HOPS complex to gain access to the cell interior should help scientists design therapeutic proteins to treat diseases that are not adequately treated using other approaches, Schepartz said.  DNA regions susceptible to breakage and loss are genetic hot spots for important evolutionary changes, according to a Stanford study.  For the English scientists involved, perhaps the most important fact is that their DNA read was about twice as long as the previous record, held by their Australian rivals.  Researchers from the University of Chicago have developed a high-throughput RNA sequencing strategy to study the activity of the gut microbiome.  Today a large international consortium of researchers published a complex but important HYPERLINK "https://www.nature.com/articles/s41586-018-0734-6" study looking at how DNA works in animals.  Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand ...  Scientists reveal how a 'molecular machine' in bacterial cells prevents fatal DNA twisting, which could be crucial in the development of new antibiotic treatments.  In new research, Hao Yan of Arizona State University and his colleagues describe an innovative DNA HYPERLINK "https://phys.org/tags/walker/" walker, capable of rapidly traversing a prepared track.  Just like any long polymer chain, DNA tends to form knots. Using technology that allows them to stretch DNA molecules and image the behavior of these knots, MIT researchers have discovered, for the first time, the factors that determine whether a knot moves along the strand or "jams" in place. 
Comments: 48 Pages.
[v1] 2019-04-29 09:19:38
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