Physics of Biology


RNA Sequencing Cellular Function

Authors: George Rajna

A new technique developed by scientists at the Broad Institute of MIT and Harvard gives an unprecedented view of the cellular organization of tissues. [25] An LMU team has improved both the sensitivity and efficiency of a popular method for single-cell RNA sequencing, which yields a molecular fingerprint for individual cells based on their patterns of gene activity. [24] The goal is to find bits of DNA in common between the known relatives and the unidentified remains, suggesting both belong to a particular lineage. One analysis develops a profile that combines what's found at 23 spots in the DNA, for example. [23] A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. [22]

Comments: 41 Pages.

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[v1] 2019-03-30 08:20:06

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