Authors: George Rajna
A new technique developed by scientists at the Broad Institute of MIT and Harvard gives an unprecedented view of the cellular organization of tissues.  An LMU team has improved both the sensitivity and efficiency of a popular method for single-cell RNA sequencing, which yields a molecular fingerprint for individual cells based on their patterns of gene activity.  The goal is to find bits of DNA in common between the known relatives and the unidentified remains, suggesting both belong to a particular lineage. One analysis develops a profile that combines what's found at 23 spots in the DNA, for example.  A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. 
Comments: 41 Pages.
[v1] 2019-03-30 08:20:06
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