I statistically analyzed 27 patients with neurofibromatosis type 1. Since the 1930's, it has been said that the neurofibromatosis type 1 born to affected mothers is very serious. It is called "maternal effect". But many are against the opinion. The result of my examination is as follows. The male cases born to affected mothers or the female cases born to affected fathers have extremely possibility of having malignant tumors. The male cases born to affected fathers or the female cases born to affected mathers or those who were new mutations didn't have malignant tumors. They were all benign. "When the tumor is found in the male cases born to affected mothers or female cases born to affected fathers, it is extremely possible that the tumor is malignant." I newly name it "cross effect".
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