Authors: George Rajna
An LMU team has improved both the sensitivity and efficiency of a popular method for single-cell RNA sequencing, which yields a molecular fingerprint for individual cells based on their patterns of gene activity.  The goal is to find bits of DNA in common between the known relatives and the unidentified remains, suggesting both belong to a particular lineage. One analysis develops a profile that combines what's found at 23 spots in the DNA, for example.  A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions.  Bacterial systems are some of the simplest and most effective platforms for the expression of recombinant proteins.  Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage.  A microscopic thread of DNA evidence in a public genealogy database led California authorities to declare this spring they had caught the Golden State Killer, the rapist and murderer who had eluded authorities for decades.  Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure.  An LMU team now reveals the inner workings of a molecular motor made of proteins which packs and unpacks DNA.  Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems.  What makes particles self-assemble into complex biological structures?  Scientists from Moscow State University (MSU) working with an international team of researchers have identified the structure of one of the key regions of telomerase—a so-called "cellular immortality" ribonucleoprotein. 
Comments: 40 Pages.
[v1] 2018-08-01 05:20:37
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