Authors: George Rajna
A novel technique developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) will help shine new light on biological questions by improving the quality and quantity of information that can be extracted in fluorescence microscopy.  Micro-computed tomography or "micro-CT" is X-ray imaging in 3-D, by the same method used in hospital CT (or "CAT") scans, but on a small scale with massively increased resolution.  A new experimental method permits the X-ray analysis of amyloids, a class of large, filamentous biomolecules which are an important hallmark of diseases such as Alzheimer's and Parkinson's.  Thumb through any old science textbook, and you'll likely find RNA described as little more than a means to an end, a kind of molecular scratch paper used to construct the proteins encoded in DNA.  Just like any long polymer chain, DNA tends to form knots. Using technology that allows them to stretch DNA molecules and image the behavior of these knots, MIT researchers have discovered, for the first time, the factors that determine whether a knot moves along the strand or "jams" in place.  Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure.  An LMU team now reveals the inner workings of a molecular motor made of proteins which packs and unpacks DNA.  Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems.  What makes particles self-assemble into complex biological structures? 
Comments: 45 Pages.
[v1] 2018-06-09 05:15:52
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