Authors: Ilija Barukčić
Objective: Cervical cancer is the second most prevalent cancer in females worldwide. Infection with human papillomavirus (HPV) is regarded as the main risk factor of cervical cancer. Our objective was to conduct a qualitative systematic review of some case-control studies to examine the role of human papillomavirus (HPV) in the development of human cervical cancer beyond any reasonable doubt. Methods: We conducted a systematic review and re-analysis of some impressive key studies aimed to answer the following question. Is there a cause effect relationship between human papillomavirus (HPV) and cervical cancer? The method of the conditio sine qua non relationship was used to proof the hypothesis whether the presence of human papillomavirus (HPV) guarantees the presence of cervical carcinoma. In other words, if human papillomavirus (HPV) is present, then cervical carcinoma is present too. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between human papillomavirus (HPV) and cervical carcinoma. Significance was indicated by a p-value of less than 0.05. Result: One study was able to provide strict evidence that human papillomavirus (HPV) is a conditio sine qua non (a necessary condition) of cervical carcinoma while the other studies analyzed failed on this point. The studies analyzed provide impressive evidence of a cause-effect relationship between human papillomavirus (HPV) and cervical carcinoma. Conclusion: Human papillomavirus (HPV) is the cause of cervical carcinoma.
[v1] 2017-11-18 05:44:37
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