Authors: Ilija Barukčić
Background: The aim of this study is to evaluate the possible relationship between human papillomavirus (HPV) and malignant melanoma. Objectives: In this systematic review we re-analysed the study of Roussaki-Schulze et al. and the study of La Placa et al. so that some new inferences can be drawn. Materials and methods: Roussaki-Schulze et al. obtained data from 28 human mel-anoma biopsy specimens and from 6 healthy individuals. La Placa et al. investigated 51 primary melanoma (PM) and in 20 control skin samples. The HPV DNA was de-termined by polymerase chain reaction (PCR). Statistical Analysis: The method of the conditio per quam relationship was used to proof the hypothesis whether the presence of human papillomavirus (HPV) guarantees the presence of malignant melanoma. In other words, if human papillomavirus (HPV) is present, then malignant melanoma is present too. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between human papillomavirus (HPV) and malignant melanoma. Signifi-cance was indicated by a p-value of less than 0.05. Results: Based on the data as published by Roussaki-Schulze et al. and the data of La Placa et al. the presence of human papillomavirus (HPV) guarantees the presence of malignant melanoma. In other words, human papillomavirus (HPV) is a conditio per quam of malignant melanoma. In contrast to the study of La Placa et al. and contrary to expectation, the study of Roussaki-Schulze et al. which is based on a very small sample size failed to provide evidence of a significant cause effect relationship be-tween human papillomavirus (HPV) and malignant melanoma. Conclusions: Human papillomavirus (HPV) is a necessary condition of malignant melanoma. Human papillomavirus (HPV) is a cause of malignant melanoma.
Comments: 13 pages. Copyright © 2017 by Ilija Barukčić, Jever, Germany. All rights reserved. Published by:
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