Biochemistry

   

Studies on HIV Resistance to Multiple Drug Therapy (Lamivudine, Zidovudine and Nevirapine) in Benin Metropolis, Nigeria

Authors: Ibeh IN, Okungbowa, Ibeh NI, Isitua CC

Resistance to anti-retroviral drugs has long been recognized as a possible occurrence which may further complicate the management and control of microbial infections including the dreaded Human Immuno Deficiency Virus (HIV) infection. The present study evaluates cases of suspected unresponsiveness to Lamivudine, Zidovudine and Nevirapine (HAART) in Benin City Nigeria. Five adult males and females (3m, 2f) between the ages of 35 - 50 years who had been on triple drug therapy (LZN) for a minimum of five years and were terminally ill in hospitals were recruited for this study. Venous blood (5.0mls) was collected from the subjects for analysis for viral antibodies, CD4 + T cells and viral load determination. The subjects were then placed on 10.0g of Manna and 20.0mls of Bioclean II daily and observed for 120 days. Venous blood samples were collected again at 30, 60, 90 and 120 days after commencement of treatment for analysis. Skin rashes disappeared after 60days. There were increases in Body weight from 47.4(Kg) to 62.4kg, CD4+ T cells from 47.3 cells/µl to 327.8 and a reduction of viral load from 253,671.5 copies/ml to 23, 240.3 copies.ml after 90 days. This finding suggests that the viruses carried by the individuals investigated in this study were not responding to Lamivudine + Zidevudine + Nevirapine. The implication is that resistance to HAART may be developing challenges to the management of HIV/AIDS in this community. You can submit your Manuscripts at:  https://symbiosisonlinepublishing.com/submitManuscript.php 

Comments: 3 Pages.

Download: PDF

Submission history

[v1] 2017-08-28 02:14:22

Unique-IP document downloads: 2 times

Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus