Biochemistry

   

Contralateral Prophylactic Mastectomies: Correlations Between Primary Tumor and Histological Findings of Controlateral Breast

Authors: Vitale V, Mattei MS, Lombardi A, Maggi S, Stanzani G, Di Stefano D, Argento G, Cunsolo G, Campanella L, Mastrangeli MR, Amanti C

Backgound: In Italy in 2015 48,000 new cases of breast carcinomas were diagnosed. Women who are diagnosed with breast cancer have a significant risk of developing contralateral breast cancer during the rest of their lives and this risk is closely associated to the family history, to the onset of breast cancer at a young age and is expressed at about 0.5 to 1% of metachronous tumors per year. The purpose of this work was to evaluate which and how many neoplastic lesions were seen in the contralateral breast that underwent prophylactic mastectomy and to understand what factors predict the appearance of such lesions. Methods: 168 bilateral mastectomies were analyzed in patients with an average age of 47 years, carried out from July 2008 to April 2016, at the Breast Unit of the Sant’Andrea Hospital. We considered women of any age suffering from unilateral breast cancer without either clinical or radiological evidence of a malignant lesion in the contralateral breast and negative for mutations of the BRCA1-BRCA2 genes test. Of the 168 bilateral mastectomies 35 patients were excluded from the study because they underwent neoadjuvant chemotherapy, another 35 patients because they were suffering from a bilateral neoplasia and 7 cases because they had mutated BRCA1 or BRCA2 genes. You can submit your Manuscripts at:  https://symbiosisonlinepublishing.com/submitManuscript.php 

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[v1] 2017-08-26 02:15:21

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