Quantitative Biology


Combining Genetic Similarities Among Known Relatives that Connect to an Unknown Relative

Authors: Stephen P. Smith, Cambrian Lopez, Nicole Lam

Various DNA testing companies promise their customers a collection of genetic matches to facilitate finding family members. The matches are in centimorgans (cM), where the higher the cM value the closer the relationship to a customer (R). Unless the relationship is close, such as parent-offspring or among 1st cousins, a single cM value is not that informative if the goal is to locate family. This paper describes a statistical method that combines a collection cM values from a cluster of unknown relatives of R, but where the cluster members are known among themselves being for example 2rd and 3th cousins. A presumed envoy is attached to the cluster, where R is a descendant of the envoy, and the various cM values are combined to provide an overall cM value between R and the envoy. The envoy’s cM comes with a statistical error to judge significance. Unlike a single cM value on a typical unknown relative, the envoy’s cM can be quite large and indicative of a real genetic path to R that has previously been undiscovered. This paper describes the method for two sisters, where the path from the envoy led to their lost father, a father that was later discovered.

Comments: 15 Pages.

Download: PDF

Submission history

[v1] 2017-05-19 14:06:52

Unique-IP document downloads: 86 times

Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus