This paper simply links the findings of Zheng, Lorenzo and Beal (2017) to our previous work on strand biased and codon-context mutation signatures in B lymphocytes (Ig SHM) and codon-contexted exome-wide point mutation patterns in cancer genomes. We conclude that in vivo the A-to-I DNA editing component at RNA: DNA hybrids occurring in Transcription Bubbles, while important, is of far lower A-to-I editing efficiency than in dsRNA substrates (as shown in Zheng et al 2017). The extreme strand biased mutation patterns documented by us in vivo should be logically rationalized by the predicted sequential steps of the RNA/RT-based mechanism.
Comments: 9 Pages.
Unique-IP document downloads: 27 times
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.