Mechanism of Somatic Hypermutation in Immunity and Cancer: Critical Analysis of "DNA Editing in Dna/rna Hybrids by Adenosine Deaminases that Act on RNA" by Zheng y, Lorenzo C and Beal pa (2017) Nucl Acids Research 2017 in Press Doi: 10.1093/nar/gkx050

Authors: Edward J Steele, Robyn A Lindley

This paper simply links the findings of Zheng, Lorenzo and Beal (2017) to our previous work on strand biased and codon-context mutation signatures in B lymphocytes (Ig SHM) and codon-contexted exome-wide point mutation patterns in cancer genomes. We conclude that in vivo the A-to-I DNA editing component at RNA: DNA hybrids occurring in Transcription Bubbles, while important, is of far lower A-to-I editing efficiency than in dsRNA substrates (as shown in Zheng et al 2017). The extreme strand biased mutation patterns documented by us in vivo should be logically rationalized by the predicted sequential steps of the RNA/RT-based mechanism.

Comments: 9 Pages.

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Submission history

[v1] 2017-02-01 01:18:48
[v2] 2017-02-01 15:44:58

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