Authors: Ilija Barukčić
Background: Many studies documented an association between a Helicobacter pylori infection and the development of human gastric cancer. None of these studies were able to identify Helicobacter pylori as a cause or as the cause of human gastric cancer. The basic relation between gastric cancer and Helicobacter pylori still remains uncer-tain. Objectives: This systematic review and re-analysis of Naomi Uemura et al. available long-term, prospective study of 1526 Japanese patients is performed so that some new and meaningful inference can be drawn. Materials and Methods: Data obtained by Naomi Uemura et al. who conducted a long-term, prospective study of 1526 Japanese patients with a mean follow up about 7.8 years and endoscopy at enrolment and in the following between one and three years after enrolment were re-analysed. Statistical analysis used: The method of the conditio sine qua non relationship was used to proof the hypothesis without a helicobacter pylori infection no development of human gastric cancer. The mathematical formula of the causal relationship was used to proof the hypothesis, whether there is a cause effect relationship between a helicobacter pylori infection and human gastric cancer. Significance was indicated by a P value of less than 0.05. Results: Based on the data published by Uemura et al. we were able to make evidence that without a helicobacter pylori infection no development of human gastric cancer. In other words, a Helicobacter pylori infection is a conditio sine qua non of human gastric cancer. In the same respect, the data of Uemura et al. provide a significant evidence that a helicobacter pylori infection is the cause of human gastric cancer. Conclusions: Without a Helicobacter pylori infection no development of human gastric cancer. Hel-icobacter pylori is the cause (k=+0,07368483, p Value = 0.00399664) of human gastric cancer.
Comments: 9 Pages. Copyright © 2016 by Ilija Barukčić, Jever, Germany. Published by:
[v1] 2017-01-02 10:00:30
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