In this article, we use system dynamical model (base on a set of nonlinear differential equations) and stochastic process model (Master equations of elementary reaction) to simulate the T helper cell differentiation (including Th1-Th2-Th17-Treg), especially the Th1-Th2 differentiations signaling network. We draw a conclusion that the critical trigger factor of naive T helper cells differentiation is the concentration of differentiation induced cytokines. We also compare the result of these two models as well as discussed the advantage and disadvantage of them.
Comments: 17 Pages.
Unique-IP document downloads: 126 times
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.