Quantitative Biology

   

The Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1 the Simulation of Th1-Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell Differentiation by Th2 Cell di

Authors: Peisheng Shi, Hai Zhang, Zhiguo Zhu

In this article, we use system dynamical model (base on a set of nonlinear differential equations) and stochastic process model (Master equations of elementary reaction) to simulate the T helper cell differentiation (including Th1-Th2-Th17-Treg), especially the Th1-Th2 differentiations signaling network. We draw a conclusion that the critical trigger factor of naive T helper cells differentiation is the concentration of differentiation induced cytokines. We also compare the result of these two models as well as discussed the advantage and disadvantage of them.

Comments: 17 Pages.

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Submission history

[v1] 2013-08-26 23:13:28
[v2] 2013-08-31 14:45:28
[v3] 2013-10-07 00:48:19

Unique-IP document downloads: 145 times

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