This short technical paper advocates a bootstrapping algorithm from which we can form a statistically reliable opinion based on limited clinically observed data, regarding whether an osteo-hyperplasia could actually be a case of Ewing's osteosarcoma. The basic premise underlying our methodology is that a primary bone tumour, if it is indeed Ewing's osteosarcoma, cannot increase in volume beyond some critical limit without showing metastasis. We propose a statistical method to extrapolate such critical limit to primary tumour volume. Our model does not involve any physiological variables but rather is entirely based on time series observations of increase in primary tumour volume from the point of initial detection to the actual detection of metastases.
Comments: 12 pages
[v1] 8 Mar 2010
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